Comparative Outcomes of Fractional Flow Reserve and Intravascular Ultrasound Guidance for Percutaneous Coronary Intervention in Intermediate Lesions: A Systematic Review and Meta‐Analysis

Eyad Jamileh; Zuha Akhtar; Kanita Farooq; Maria Babu; Mohamed Xamza; Ibrahim Antoun

doi:10.1155/cdr/6570642

January 1, 2026Cardiovascular TherapeuticsOpen Access

Comparative Outcomes of Fractional Flow Reserve and Intravascular Ultrasound Guidance for Percutaneous Coronary Intervention in Intermediate Lesions: A Systematic Review and Meta‐Analysis

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Key Points

This research aims to compare the effectiveness of fractional flow reserve (FFR) and intravascular ultrasound (IVUS) in guiding percutaneous coronary interventions (PCI) for intermediate lesions.
Conducted a systematic review and meta-analysis of existing studies.
Compared outcomes between FFR and IVUS guidance on PCI procedures.
Assessed major adverse cardiovascular events (MACE), mortality, myocardial infarction (MI), and target vessel revascularization (TVR).
Both FFR and IVUS demonstrated similar outcomes for guiding PCI.
No significant differences in MACE, mortality, or MI between the two modalities.
FFR and IVUS effectively guided similar volumes of PCI procedures.

Implication

Systematic review finds similar outcomes for FFR and IVUS in coronary intervention, suggesting tailored modality selection.

Abstract

FFR and IVUS are both effective for guiding PCI, with similar outcomes in terms of MACE, mortality, MI, TVR and PCI procedures performed. Modality selection should be tailored to lesion complexity, institutional expertise and resource availability.

Discussion

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Cite This Study

Jamileh et al. (2026) studied this question.

synapsesocial.com/papers/69c8c30dde0f0f753b39d928 https://doi.org/10.1155/cdr/6570642

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Comparative Outcomes of Fractional Flow Reserve and Intravascular Ultrasound Guidance for Percutaneous Coronary Intervention in Intermediate Lesions: A Systematic Review and Meta‐Analysis

Key Points

Implication

Abstract

Discussion

Cite This Study

Comparative Outcomes of Fractional Flow Reserve and Intravascular Ultrasound Guidance for Percutaneous Coronary Intervention in Intermediate Lesions: A Systematic Review and Meta‐Analysis

Key Points

Implication

Abstract

Discussion

Cite This Study

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