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Randomised controlled trial shows topical probiotics improve wound healing in diabetic foot ulcers, suggesting a valuable treatment option.
In this double-blind randomised controlled trial of 58 patients with 58 diabetic foot ulcers, a topical probiotic formulation in soybean concentrate significantly accelerated wound healing compared with placebo. The mean time to complete healing was 89.6 vs. 165.9 days (P = 0.012), with higher healing rates from week 20 onwards. The treatment was safe and well tolerated, supporting topical probiotics as a promising adjunctive therapy for chronic diabetic foot ulcers.
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Hsu et al. (2026) studied this question.
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