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March 29, 2026Organic Chemistry Frontiers1 citations

Carbon dioxide as a methylene donor: modular synthesis of 3-aminomethyl chromones via a reductive tandem reaction †

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YZYubing ZhouZXZhongrong XuWLWei Li

Key Points

  • The aim is to develop a method that uses carbon dioxide as a methylene donor for synthesizing 3-aminomethyl chromones.
  • Developed a reductive tandem protocol
  • Used o-hydroxyaryl enaminones and amines as starting materials
  • Utilized carbon dioxide as a methylene source
  • Successfully generated 3-aminomethyl chromones
  • Demonstrated modular assembly process
  • Showed potential for using carbon dioxide in organic synthesis

Abstract

A reductive tandem protocol that harnesses CO₂ as a methylene source is reported, enabling direct and modular assembly of biologically relevant 3-aminomethyl chromones from simple o-hydroxyaryl enaminones and amines. The...

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Cite This Study

Zhou et al. (2026) studied this question.

synapsesocial.com/papers/69c8c371de0f0f753b39e3fehttps://doi.org/10.1039/d6qo00205f
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