Reports stable translocator protein levels in cognitive regions of virally suppressed people with HIV, suggesting potential implications for brain health.
[11C]DPA-713 positron emission tomography (PET) has shown higher translocator protein (TSPO) availability, a marker of glial response, in cognitive control and declarative memory brain regions of virally suppressed people with HIV (VS-PWH). Here, 14 VS-PWH completed repeat TSPO PET after ~18 months. Regional TSPO was largely time-stable, with modest variability in some participants that was unrelated to antiretroviral therapy. Further study of a stable, higher TSPO density in select brain regions of VS-PWH is warranted.
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Rubin et al. (2026) studied this question.
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