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March 29, 2026International Journal of SurgeryOpen Access

Deciphering the association between uric acid and kidney stones: insights into the mediating roles of BMI and serum iron: a cross-sectional study based on NHANES 2007–2018

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Authors

KLKen LiCCChu Ann ChaiYTYi Quan Tan

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Overview

A cross-sectional study explores how uric acid impacts kidney stone prevalence in U.S. adults, suggesting mediation by BMI and serum iron.

Key Points

  • This study investigates the link between serum uric acid levels and kidney stone prevalence in U.S. adults.
  • Analyzed data from 24,039 U.S. adults from NHANES 2007-2018.
  • Employed multivariable logistic regression models to assess the UA-KS relationship.
  • Conducted mediation analysis to evaluate BMI and serum iron as mediators.
  • Used restricted cubic splines to explore nonlinear associations.
  • Performed subgroup analyses to address demographic variations.
  • Higher serum UA levels significantly correlate with an increased KS prevalence (OR = 1.001, P < 0.001).
  • Association remained significant after adjusting for age, sex, and race.
  • UA levels showed no relationship with KS recurrence.
  • Serum iron partially mediated the relationship (2.7%) and BMI had a larger mediating effect (20.0%).

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69c8c3a8de0f0f753b39e91bhttps://doi.org/10.1097/js9.0000000000005126
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