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March 29, 2026Microorganisms0 citationsOpen Access

Transcriptomic and RNA Modification Analysis of Severe Fever with Thrombocytopenia Syndrome Virus

Transcriptomic and RNA Modification Landscape of Severe Fever with Thrombocytopenia Syndrome Virus Revealed by Nanopore Direct RNA Sequencing

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Authors

HYHaowen YuanBZBohan ZhangLQLing Qiu

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Overview

Reveals RNA modification and transcript architecture in SFTSV-infected cells, suggesting new research directions.

Key Points

  • The research aims to analyze the RNA characteristics and modifications of the SFTSV in infected cells.
  • Used Oxford Nanopore direct RNA sequencing for native SFTSV RNA analysis.
  • Conducted strand-specific alignment and isoform reconstruction through read endpoint clustering.
  • Performed isoform-level quantification and signal-level modification identification.
  • Identified a 'length-layering' pattern in SFTSV transcription with a few full-length and many truncated isoforms.
  • Discovered predominant RNA modifications, including Ψ and m5C, with a sparse presence of m6A.
  • Modification hotspots were found co-located across isoforms, indicating regulated transcript termination.

Cite This Study

Yuan et al. (2026) studied this question.

synapsesocial.com/papers/69c8c43ede0f0f753b39ef19https://doi.org/10.3390/microorganisms14040756
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