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March 27, 2026Clinical and Experimental Health Sciences

Dose-Dependent Antiproliferation and αvβ3 Expression Downregulation by Phenylboronic Acid in SK-OV-3 and MIA-Pa-Ca-2

Bircan Kolbaşı Turan Acar Muhammet Volkan Bulbul Azat Polat Kaan Sapmaz İ. Gürkan KESKİN

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Key Points

The aim is to investigate the effects of phenylboronic acid on cancer cell proliferation and integrin expression in specific cell lines.
Cultured SK-OV-3 and MIA-Pa-Ca-2 cells under standard conditions.
Treated cells with phenylboronic acid concentrations from 10 to 500 μM.
Conducted MTT assays for cell viability and immunofluorescence for αvβ3 integrin expression.
IC₅₀ values were 264.8 μM for SK-OV-3 and 294.4 μM for MIA-Pa-Ca-2 after 24 hours.
Immunofluorescence showed a dose-dependent decrease in αvβ3 integrin levels in both cell lines.

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Implication

Demonstrates antiproliferation effects of phenylboronic acid in ovarian and pancreatic cancer cells, suggesting potential therapeutic roles.

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Cite This Study

Kolbaşı et al. (2026) studied this question.

synapsesocial.com/papers/69c8c43ede0f0f753b39ef1e https://doi.org/10.33808/clinexphealthsci.1764284

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