Elevating the standards of hypofibrinogenemia in trauma: Higher thresholds of admission fibrinogen predict mortality and organ dysfunction

Justin E. Richards; Joseph A. Kufera; Mary E. Burgoyne; Deborah M. Stein; Rosemary Kozar

doi:10.1111/trf.70200

March 28, 2026Transfusion

Elevating the standards of hypofibrinogenemia in trauma: Higher thresholds of admission fibrinogen predict mortality and organ dysfunction

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Key Points

The aim is to determine the impact of admission fibrinogen levels on mortality and organ dysfunction in trauma patients.
Analyzed fibrinogen levels upon admission in trauma patients
Evaluated the relationship between fibrinogen levels and 28-day/24-hour mortality
Assessed post-traumatic acute kidney injury (AKI) and acute respiratory distress syndrome (ARDS)
Admission hypofibrinogenemia <200 mg/dL is linked to increased 28-day mortality
Higher fibrinogen correlates with lower organ dysfunction rates
Fibrinogen also serves as a marker for AKI and ARDS after trauma

Implication

Elevating standards of hypofibrinogenemia shows higher admission fibrinogen predicts mortality and organ dysfunction in trauma patients.

Abstract

Admission hypofibrinogenemia <200 mg/dL is associated with 28-day and 24 h mortality in trauma patients. Admission fibrinogen is also a marker for post-traumatic AKI and ARDS.

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Cite This Study

Richards et al. (2026) studied this question.

synapsesocial.com/papers/69c9c51bf8fdd13afe0bcfea https://doi.org/10.1111/trf.70200

View at Publisher

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Elevating the standards of hypofibrinogenemia in trauma: Higher thresholds of admission fibrinogen predict mortality and organ dysfunction

Key Points

Implication

Abstract

Discussion

Cite This Study

Elevating the standards of hypofibrinogenemia in trauma: Higher thresholds of admission fibrinogen predict mortality and organ dysfunction

Key Points

Implication

Abstract

Discussion

Cite This Study

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