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March 30, 2026CNS Neuroscience & Therapeutics2 citationsOpen Access

Low‐Intensity Pulsed Ultrasound Promotes Spinal Cord Injury Recovery by Regulating Microglia‐Mediated Neuroinflammation

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XLXiao LiYLYang LiuWLWanghui Liu

Key Points

  • To evaluate the effects of low-intensity pulsed ultrasound on neuroinflammation and recovery after spinal cord injury.
  • Utilized low-intensity pulsed ultrasound (LIPUS) in spinal cord injury models.
  • Analyzed microglial activation and neuroinflammatory markers post-treatment.
  • Investigated signaling pathways including NOD-like receptor and IL-17.
  • LIPUS significantly reduced neuroinflammation in spinal cord injury models.
  • Improved neurological function was observed following LIPUS treatment.
  • Downregulation of CXCR2 and modulation of hub genes were noted.

Abstract

LIPUS effectively alleviates neuroinflammation after SCI and promotes neurological function recovery by regulating microglia-mediated neuroinflammation, whose mechanism is associated with the modulation of NOD-like receptor, IL-17 signaling pathways and the downregulation of hub genes such as CXCR2. This study provides a scientific basis for the clinical application of LIPUS in SCI treatment and a theoretical foundation for exploring multi-modal therapeutic strategies combining LIPUS with other therapies.

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Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69c9c57ff8fdd13afe0bd74fhttps://doi.org/10.1002/cns.70849
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