Population pharmacokinetic analysis of rivaroxaban in healthy volunteers and patients with radiofrequency ablation of non-valvular atrial fibrillation in China

Figures

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  FIGURE 1. Goodness-of-fit plot of the final model. (A) Observed concentrations versus IPERD. (B) Observed concentrations versus PRED. (C) CWRES versus PRED. (D) CWRES versus time. Black lines represent the identity lines in (A,B), while in (C) and (D), they represent the position where CWRES equals 0. Red lines represent the nonparametric regression lines.

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  FIGURE 2. pcVPC results of the final model. The solid line and dashed lines, respectively, represent the median and 95% CI of the observations. Open circles represent the observed concentrations. The shaded red area represents the 95% CI of medians, and the shaded blue areas stand for the 95% CI of the 2.5th and 97.5th percentiles of the simulation results.

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  FIGURE 3. The effect of significant covariates on rivaroxaban exposure (AUC0–inf).

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  FIGURE 4. The effect of concomitant drugs on the clearance rate of rivaroxaban.