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March 30, 2026SHILAP Revista de lepidopterología0 citationsOpen Access

Neutrophil-to-Lymphocyte Ratio Predicts Adverse Outcomes in ANCA-Associated Vasculitis

The neutrophil-to-lymphocyte ratio is associated with adverse outcomes in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis

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Authors

YLYunan LiYLYang LiuDZDi Zhang

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Overview

Retrospective study shows neutrophil-to-lymphocyte ratio predicts mortality in ANCA-associated vasculitis, indicating its utility in risk assessment.

Key Points

  • This study investigates the role of neutrophil-to-lymphocyte ratio (NLR) in predicting long-term outcomes in patients with ANCA-associated vasculitis (AAV).
  • Conducted a retrospective study of 532 patients diagnosed with AAV from June 2012 to June 2024.
  • Assessed all-cause mortality and end-stage renal disease (ESRD) as primary and secondary outcomes, respectively.
  • Employed logistic regression, Cox proportional hazards regression, Kaplan-Meier survival analysis, and time-dependent ROC to analyze data.
  • Higher NLR levels correlated with more severe inflammation, worse renal function, and increased disease activity.
  • Patients with NLR >10 exhibited a 77% higher risk of mortality compared to those with lower NLR levels.
  • No significant association was found between NLR and the risk of ESRD.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69ca1210883daed6ee094d3dhttps://doi.org/10.3389/fimmu.2026.1780204
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