Research demonstrates PI3K-Akt pathway involvement in senescence of tonsil mesenchymal stem cells, suggesting new regeneration strategies.
Our research proved that replicative senescence in TMSCs is associated with PI3K-Akt pathway activation, which likely orchestrates senescence via p16 and p53-p21 cascades. These findings provide new insights into the mechanisms of stem cell aging and suggest potential molecular targets for developing strategies to delay senescence in TMSCs for regenerative medicine.
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Qiu et al. (2026) studied this question.
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