Schizophrenia-associated complement C4 impairs synaptic connectivity and decreases microglia-synapse interactions through CR3 signaling

Nala Gockel; Nayadoleni Nieves-Rivera; Mélanie Druart; K. Jaako; Falko Fuhrmann; Fabrizio Musacchio; Henrike Antony; Manuel Mittag; Sophie Crux-Daseking; Stefanie Poll; B. Jansone; Martin Fuhrmann; Corentin Le Magueresse

doi:10.1016/j.celrep.2026.117161

March 27, 2026Cell ReportsOpen Access

Schizophrenia-associated complement C4 impairs synaptic connectivity and decreases microglia-synapse interactions through CR3 signaling

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Key Points

The research aims to explore how complement C4 overexpression affects synaptic connectivity and interactions between microglia and synapses.
Examined the effects of C4 overexpression on synapse density in cortical regions.
Analyzed the interactions between microglia and synapses under C4-OE conditions.
Monitored changes in synaptic function linked to complement signaling.
C4 overexpression significantly reduces cortical synapse density.
Impairment of synaptic function correlates with decreased interaction between microglia and synapses.
Observed changes implicate CR3 signaling in these effects.

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Implication

Investigates the impact of complement C4 on synaptic density in an altered microglial environment, suggesting new insights into schizophrenia-related mechanisms.

Abstract

Complement C4 overexpression (C4-OE) reduces cortical synapse density and function

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Cite This Study

Gockel et al. (2026) studied this question.

synapsesocial.com/papers/69ca12d4883daed6ee0951b1 https://doi.org/10.1016/j.celrep.2026.117161

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Schizophrenia-associated complement C4 impairs synaptic connectivity and decreases microglia-synapse interactions through CR3 signaling

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Schizophrenia-associated complement C4 impairs synaptic connectivity and decreases microglia-synapse interactions through CR3 signaling

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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