Post-hoc analysis reveals survival differences in perihilar cholangiocarcinoma patients, indicating implications for treatment strategies.
Key Points
This study aims to quantify how survival in perihilar cholangiocarcinoma can be explained by biological patient selection using the Mayo Clinic eligibility criteria.
Conducted a post-hoc analysis of patients undergoing liver resection for pCCA from January 2005 to December 2023.
Stratified patients based on adapted Mayo Clinic eligibility criteria.
Analyzed overall survival and recurrence-free survival using Kaplan-Meier estimates and Cox regression.
Out of 305 patients, 54 (17.7%) met Mayo Clinic eligibility criteria.
Median overall survival was 4.1 years for patients meeting criteria versus 2.2 years for those who did not (p=0.004).
Median recurrence-free survival was 3.6 years for those meeting criteria compared to 1.5 years for others (p=0.005).
Mayo Clinic criteria was not an independent predictor for survival after adjusting for other prognostic factors.