What question did this study set out to answer?

This research aims to explore the relationship between grey matter volume and dimensionally assessed personality functioning in female youths with varying degrees of Borderline Personality Disorder.

March 31, 2026NeuroImage ClinicalOpen Access

Grey matter volume associations with personality functioning in a clinical cohort of female youths

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Authors

MTMadelyn ThomsonBern University of Applied Sciences MCMarialuisa CaveltiUniversity of Bern IMInes Mürner-LavanchyUniversity of Bern

Discussion

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Implication

Volumetric analysis shows no link between personality functioning and grey matter volume in youths with BPD, highlighting the need for further research.

Key Points

This research aims to explore the relationship between grey matter volume and dimensionally assessed personality functioning in female youths with varying degrees of Borderline Personality Disorder.
Participants included 93 females aged 14-21 with full-threshold BPD, sub-threshold BPD, and healthy controls.
Structural Magnetic Resonance Imaging (sMRI) was performed to assess grey matter volume (GMV).
The Semi-Structured Interview for Personality Functioning DSM-5 (STiP-5.1) was used to measure personality functioning.
Multiple linear regression analyses were conducted to explore associations between STiP-5.1 scores and GMV.
No significant association was found between STiP-5.1 total scores and total GMV (p = 0.61).
Individual brain region analyses also yielded non-significant results (all corrected p values ≥0.82).
Validity checks using BPD criteria confirmed the non-significant findings.

Cite This Study

Thomson et al. (2026) studied this question.

synapsesocial.com/papers/69cb6526e6a8c024954b943d https://doi.org/10.1016/j.nicl.2026.103988

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March 31, 2026NeuroImage ClinicalOpen Access

Grey matter volume associations with personality functioning in a clinical cohort of female youths

View Full Paper

Ask AI

Bookmark

Authors

MTMadelyn ThomsonBern University of Applied Sciences MCMarialuisa CaveltiUniversity of Bern IMInes Mürner-LavanchyUniversity of Bern

Discussion

Member takes

Implication

Volumetric analysis shows no link between personality functioning and grey matter volume in youths with BPD, highlighting the need for further research.

Key Points

This research aims to explore the relationship between grey matter volume and dimensionally assessed personality functioning in female youths with varying degrees of Borderline Personality Disorder.
Participants included 93 females aged 14-21 with full-threshold BPD, sub-threshold BPD, and healthy controls.
Structural Magnetic Resonance Imaging (sMRI) was performed to assess grey matter volume (GMV).
The Semi-Structured Interview for Personality Functioning DSM-5 (STiP-5.1) was used to measure personality functioning.
Multiple linear regression analyses were conducted to explore associations between STiP-5.1 scores and GMV.
No significant association was found between STiP-5.1 total scores and total GMV (p = 0.61).
Individual brain region analyses also yielded non-significant results (all corrected p values ≥0.82).
Validity checks using BPD criteria confirmed the non-significant findings.

Cite This Study

Thomson et al. (2026) studied this question.

synapsesocial.com/papers/69cb6526e6a8c024954b943d https://doi.org/10.1016/j.nicl.2026.103988

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