Why the study?
Does smoking trigger RA-specific immune reactions to citrullinated proteins in the context of HLA-DR SE genes?
Does smoking trigger RA-specific immune reactions to citrullinated proteins in the context of HLA-DR SE genes?
Smoking is identified as an environmental trigger for specific autoimmunity in a genetically susceptible subset of rheumatoid arthritis patients.
No immediate change to smoking advice for RA prevention; extends evidence for HLA-SE-smoking interaction in citrullinated autoimmunity.
We identified an environmental factor, smoking, that in the context of HLA-DR SE genes may trigger RA-specific immune reactions to citrullinated proteins. These data thus suggest an etiology involving a specific genotype, an environmental provocation, and the induction of specific autoimmunity, all restricted to a distinct subset of RA.
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Klareskog et al. (2005) studied this question.
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