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April 1, 2026PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS

Primary Cilium-mediated Mechano-metabolic Coupling: Cross-system Homeostatic Regulation of The Nervous, Bone, Vascular, and Renal Systems

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Authors

LDLiang-Chen DUANHHHaoliang HuSWShuzhi Wang

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Overview

This review explores mechano-metabolic coupling in various systems, highlighting implications for systemic health and disease.

Key Points

  • The aim is to understand the role of primary cilia in regulating systemic homeostasis across multiple organ systems.
  • Review of existing literature on primary cilia in nervous, bone, vascular, and renal systems.
  • Analysis of ciliary signaling mechanisms and their implications for metabolic processes.
  • Identification of pathways linking ciliary function to systemic health.
  • Primary cilia integrate mechanical stimuli with metabolic signaling to maintain homeostasis.
  • Dysfunction of primary cilia is linked to disorders like obesity and polycystic kidney disease.
  • Different ciliary pathways were identified, influencing systemic pathology and potential therapeutic directions.

Cite This Study

DUAN et al. (2026) studied this question.

synapsesocial.com/papers/69ccb55116edfba7beb87515https://doi.org/10.3724/j.pibb.2025.0573
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