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Diagnostic test compares ddPCR with Sanger sequencing and NGS for POLE mutations in endometrial cancer, suggesting superior accuracy.
ddPCR demonstrated superior sensitivity and specificity in detecting POLE mutations compared to Sanger sequencing and showed perfect agreement with NGS. With its rapid turnaround, simplicity, and cost-effectiveness, ddPCR is highly suitable for routine clinical use, potentially enhancing patient management and outcomes in EC.
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Ouh et al. (2026) studied this question.
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