Experiments reveal significant antitumor effects from different drug mechanisms in advanced tumor models, suggesting potential for late-stage treatment.
The effectiveness of drugs with various mechanisms of antitumor action, representing the following classes of compounds, has been studied on the formed solid tumor: noble metals polyacrylate (aurumacryl, argacryl), binuclear dinitrosyl iron complexes (B-DNIC-cysteine), nitrosoalkilureas (methynur, dimethynur, chlonizol, nimustin). The range of tumor models included xenographs of human melanoma BRO, the first generation of spontaneous breast cancer in mice, Lewis lung carcinoma, adenocarcinoma Ca-755, melanoma B-16, leukemia P-388 (solid form). The mass of tumors when exposed to the drugs varied from 120 to 420 mg, and the time to start using the drugs ranged from 5 to 12 days of tumor growth. It is shown that it is possible in principle to achieve a very high antitumor effect with late initiation of treatment and at the effect of drugs on already formed tumors.
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Ostrovskaya et al. (2026) studied this question.
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