What question did this study set out to answer?

The study aims to evaluate the impact of consensus review on interobserver variability in nuclear atypia assessment.

April 1, 2026Diagnostic Cytopathology0 citations

Decreased Interobserver Variability in Nuclear Atypia of Undetermined Significance After Consensus Review of Thyroid Fine Needle Aspirations

HCHeather Chen‐YostUniversity of Michigan RCRichard CantleyUniversity of Michigan XJXiaobing JinUniversity of Michigan

Key Points

The study aims to evaluate the impact of consensus review on interobserver variability in nuclear atypia assessment.
Implemented a two-tiered approach for atypia of undetermined significance (AUS) assessments.
Conducted a group review of thyroid fine needle aspirations (FNAs) to assess variability.
Compared interobserver variability before and after the consensus review.
Interobserver variability decreased significantly for nuclear atypia after consensus review.
The two-tiered AUS framework helped simplify clinical evaluation processes.
Higher risk of malignancy was noted in cases with nuclear atypia, highlighting the importance of accurate assessment.

Abstract

Interobserver variability remains for TBS I, II, and III-other despite group review. The implementation of the two-tiered AUS will simplify our clinical practice and is expected to decrease interobserver variability in the use of AUS-nuclear atypia, which has a higher risk of malignancy.

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