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April 1, 2026GenesOpen Access

Gene-Agnostic Therapeutic Strategies for Inherited Retinal Diseases: Neuroprotection and Immunomodulation

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Authors

LRLucas RoweSBS. Patricia BecerraRMRobert E. MacLaren

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Overview

This review examines gene-agnostic strategies to improve vision in inherited retinal diseases, suggesting novel treatment options.

Key Points

  • The aim is to explore therapeutic methods for inherited retinal diseases that do not rely on specific genetic mutations.
  • Reviewed literature on neuroprotective and immunomodulatory strategies for inherited retinal diseases.
  • Focused on neurotrophic factors and complement system modulation.
  • Highlighted recent FDA-approved therapies and ongoing research in gene therapy.
  • Neuroprotective strategies showed effectiveness in preserving photoreceptors across various genetic backgrounds.
  • FDA approval of CNTF cell-based therapy for macular telangiectasia type 2 supports these approaches.
  • Complement system inhibitors have been approved for associated conditions, exhibiting promise for IRDs.

Cite This Study

Rowe et al. (2026) studied this question.

synapsesocial.com/papers/69ccb69d16edfba7beb88480https://doi.org/10.3390/genes17040392
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