What question did this study set out to answer?

This research aims to evaluate the dose modification effects of silver and gold nanoparticles in layered skin structures using Monte Carlo simulations.

April 1, 2026Journal of Advanced Research in Natural and Applied Sciences0 citationsOpen Access

Comparative Assessment of Silver and Gold Nanoparticles for Dose Enhancement in Layered Skin Geometries: A Monte Carlo Sensitivity Study

DEDursun EşitmezGazi Hastanesi MÇMustafa ÇağlarIstanbul Medipol University GDGülfem Süsoy DoğanIstanbul University

Key Points

This research aims to evaluate the dose modification effects of silver and gold nanoparticles in layered skin structures using Monte Carlo simulations.
Utilized Monte Carlo simulations (MCNP 6.3) to model layered skin geometries.
Embedded silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs) at concentrations of 5–30 mg/g.
Analyzed energy deposition using electron beams (6-12 MeV) and low-energy photons (50/100 keV).
Calculated and normalized dose-enhancement factors (DEFs) to assess nanoparticle impact on absorbed dose.
AgNPs showed a dose enhancement factor of ~560% at 50 keV, indicating significant improvement at low energies.
A near-linear relationship was observed between DEF and nanoparticle concentration for electron beams.
Low-energy photons exhibited substantially higher enhancement than electron beams, while adjacent normal-tissue regions remained relatively unchanged.

Abstract

This study quantifies nanoparticle-mediated dose modification in an idealized layered skin geometry using Monte Carlo (MCNP 6.3) (skin surface, epidermis ≈100 μm, dermis ≈500 μm, underlying skin). Homogeneous silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs) at 5–30 mg/g were embedded in a 1 × 1 × 1 cm³ target, and energy-deposition tallies were converted to absorbed dose and reported as dose-enhancement factors (DEFs) normalized to 0 mg/g. Electron beams (6–12 Mega Electron Volt (MeV)) produced a near-linear DEF–concentration trend in the target with modest superficial gains; in contrast, low-energy photons (50/100 Kilo Electron Volt (keV)) yielded substantially higher enhancement, with AgNPs at 50 keV reaching ~560%, while adjacent normal-tissue sampling regions (OAR1–OAR6) remained near unity with mild, orientation-dependent anisotropy. Skin-layer summaries confirmed surface-weighted increases at low energies and more uniform depth profiles at higher MeV. Statistical uncertainties were

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Eşitmez et al. (Mon,) studied this question.

synapsesocial.com/papers/69ccb71716edfba7beb88f56 https://doi.org/https://doi.org/10.28979/jarnas.1862846

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