Findings reveal that expectations affect pain-related responses in participants, suggesting caution in clinical assessments.
Our findings provide evidence that pain-related autonomic responses are modulated by expectations, even in a state of heightened sympathetic arousal, such as after experimentally-induced sensitization in healthy participants. In the context of clinical assessments, this implies that caution is warranted when interpreting unprocessed pain-related autonomic signals, such as SCR amplitudes, as surrogate markers of central sensitization.
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Allmendinger et al. (2026) studied this question.
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