Pneumatically Controlled Microfluidic Synthesis of Polymeric Nanoparticles for mRNA Delivery

Yunshan Liu; Guanyou Lin; Matthew James; Miqin Zhang

doi:10.1039/d5nr05222j

January 1, 2026Nanoscale

Pneumatically Controlled Microfluidic Synthesis of Polymeric Nanoparticles for mRNA Delivery

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Key Points

The aim is to enhance gene delivery efficiency using polymeric nanoparticles with controlled properties.
Developed a pneumatic microfluidic system for nanoparticle synthesis.
Controlled key physicochemical properties during synthesis in real-time.
Employed nanoscale techniques to optimize particle size and distribution.
Achieved narrow size distributions of polymeric nanoparticles.
Demonstrated reproducibility across multiple synthesis batches.
Showed improved loading efficiency for mRNA delivery.

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Implication

Microfluidic techniques improve the synthesis of polymeric nanoparticles for gene delivery, indicating enhanced efficiency and control.

Abstract

Efficient and reproducible gene delivery requires nanoscale carriers with well-controlled physicochemical properties, yet conventional bulk synthesis of polymeric nanoparticles (PNPs) often results in broad size distributions, batch variability, and poor...

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Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69ccb78416edfba7beb898d4 https://doi.org/10.1039/d5nr05222j

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Pneumatically Controlled Microfluidic Synthesis of Polymeric Nanoparticles for mRNA Delivery

Key Points

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Implication

Abstract

Discussion

Cite This Study

Pneumatically Controlled Microfluidic Synthesis of Polymeric Nanoparticles for mRNA Delivery

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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