Nickel-catalyzed hydroxymethylation with α-silicon N -methoxyphthalimides via radical Brook rearrangement

Xiao-Bo Liu; Muhammad Bilal; Jiaying Zuo; Yong Yu; Yang Wu; Boming Shen; Peng-Hui Shen; Hua‐Jian Xu; Yu-Feng Liang

doi:10.1039/d6sc00986g

January 1, 2026Chemical ScienceOpen Access

Nickel-catalyzed hydroxymethylation with α-silicon N -methoxyphthalimides via radical Brook rearrangement

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Key Points

The research aims to explore nickel-catalyzed hydroxymethylation using α-silicon N-methoxyphthalimides through radical mechanisms.
Conducted nickel-catalyzed reactions on aryl electrophiles.
Utilized α-silicon N-methoxyphthalimides as reactants.
Applied radical Brook rearrangement to facilitate the process.
Successfully achieved the installation of hydroxymethyl groups.
Demonstrated functional-group tolerance in diverse conditions.
Highlighted the potential for late-stage modifications in synthesis.

Implication

Nickel-catalyzed hydroxymethylation demonstrates effective group installation in aryl electrophiles, implying broader synthesis options.

Abstract

Nickel-catalyzed reductive hydroxymethylation of aryl electrophiles with α-silicon N -methoxyphthalimides via a radical Brook rearrangement enables late-stage, functional-group-tolerant installation of hydroxymethyl groups.

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Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69ccb7b016edfba7beb89b8c https://doi.org/10.1039/d6sc00986g

View Full Paper

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Nickel-catalyzed hydroxymethylation with α-silicon N -methoxyphthalimides via radical Brook rearrangement

Key Points

Implication

Abstract

Discussion

Cite This Study

Nickel-catalyzed hydroxymethylation with α-silicon N -methoxyphthalimides via radical Brook rearrangement

Key Points

Implication

Abstract

Discussion

Cite This Study

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