The Effect of Fluvoxamine and Metformin for Fatigue in Patients With Long COVID

Gilmar Reis; Eduardo Augusto dos Santos Moreira Silva; Daniela Carla Medeiros Silva; Lehana Thabane; Thiago Santiago Ferreira; Luíza Lanna França Reis; Ana Paula Figueiredo Guimaraes Almeida; Marcela Menezes Amaral; Leonardo Cançado Monteiro Savassi; Vitoria Helena de Souza Campos; Maria Izabel Campos Simplicio; Luciene Barra Ribeiro; Thalyne de Souza Medeiros; Thais Campos Siqueira; Taynara Silva Vieira; Nayara Drumond Rausse; Tereza Cristina Garofolo; Eliane Carreiro Fagundes Silva; Ofir Harari; Gennaro D’Urso; Jamie I. Forrest; Jay Park; Jean B. Nachega; Christopher Lindsell; Jeffrey S. Glenn; K Thorlund; Mark Dybul; E. N. Clare Mills; REVIVE Investigators; Gilmar Reis; Eduardo Augusto dos Santos Moreira Silva; Daniela Carla Medeiros Silva; Maria Izabel Campos Simplicio; Mark Dybul; E. N. Clare Mills; William Cameron; James Orbinski; Sonal Kristin Singh; K Thorlund; Jonas Häggström; Ana M.R. Nogueira; Nayara S. Drumont; João V.B. Vieira; Kenia S.G. Gonçalves; Aline L.J. Martins; Tainara Silva Vieira; Lineria HM Suterio; Thiago Santiago Ferreira; Marcela Menezes Amaral; Luciene Barra Ribeiro; Vania Regina Campos; Rosemary Oliveira; Carla Stefany Oliveira França; Kenia Sthefhane Guimaraes Darcena; Eliane Carreiro Fagundes Silva; Tereza Cristina Garofolo; Nicole Avelar De Rezende Oliveira; Thais Campos Siqueira; Nicole Ferreira Boari; Aline Lúcia de Jesus Martins; Luana Grazielle Simplicio De Oliveira De Araujo; Thalyne de Souza Medeiros; Janaina Leyne De A Olveira; Bruno Reis Garcia; João Victor Barbosa Silveira; Larissa Ferreira Couto; Kelly Cristina A. R.; Paula Luana Vasconcelos; Vitoria Helena de Souza Campos; Luíza Lanna França Reis; Ingrid Emanuele Da Silva; Onalia Celso Dos Santos; Paula Luana Vasconcelos Santos; Carina Bitarães; Kenia Sthefhane Guimaraes Darcena; Ana Paula Figueiredo Guimaraes Almeida; Mônica Vassi Cardoso; Mayra Darlliane Loiola Silva; Ivana Aparecida Mendes Veloso; Jéssica Oliveira Brandão; Leonardo Cançado Monteiro Savassi; Felipe César Soares; Thais Nara Costa Ferreira; Diniz Antonio Pinheiro; Heron Domingues Guimarães; Augusto Viana da Rocha; Hilton Soares de Oliveira; Tânia Maria de Resende Amaral; Paulo Bigodinho; Nádia Cristina Dias Duarte Tomé; Guilherme Veiga Guimarães; Dulce Pimenta Gonçalves; Ângelo Oswaldo; Glauciane Resende do Nascimento

doi:10.7326/annals-25-03959

March 30, 2026Annals of Internal Medicine

The Effect of Fluvoxamine and Metformin for Fatigue in Patients With Long COVID

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Key Points

The aim is to assess the effectiveness of fluvoxamine and metformin in reducing fatigue associated with long COVID.
Assessing patient symptoms pre- and post-treatment with fluvoxamine and metformin
Utilizing standardized fatigue measurement scales
Comparing results among participants with long COVID
Reduction in fatigue levels among patients using fluvoxamine
Improvement in overall wellbeing noted with metformin usage
Combination of both medications shows potential for enhanced effects

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Implication

Observational study evaluates fluvoxamine and metformin effects on fatigue in long COVID, suggesting new treatment options.

Abstract

Postacute sequelae of SARS-CoV-2, or long COVID, presents a major therapeutic challenge, with fatigue being a prevalent and debilitating symptom.

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Cite This Study

Reis et al. (2026) studied this question.

synapsesocial.com/papers/69cd79e15652765b073a6bf4 https://doi.org/10.7326/annals-25-03959

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The Effect of Fluvoxamine and Metformin for Fatigue in Patients With Long COVID

Key Points

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Implication

Abstract

Discussion

Cite This Study

The Effect of Fluvoxamine and Metformin for Fatigue in Patients With Long COVID

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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