A nanoscale cascade system integrating calcium interference with phototherapy–chemotherapy synergy for enhanced antitumor efficacy

Key Points

• To develop a system that leverages calcium release to improve the effectiveness of chemotherapy and phototherapy against tumors.
• Constructed a PB@PAA-CaO 2 @PDA platform
• Integrated calcium release with drug loading
• Applied photothermal conversion methods
• Achieved efficient antitumor efficacy
• Demonstrated synergy between calcium overload and therapies
• Improved drug delivery and therapeutic outcomes through the system