Tissue harmonic imaging has superior spatial and contrast resolution compared to conventional linear imaging but suffers from low signal-to-noise ratio (SNR). While phase-encoded excitation can be used to improve the harmonic SNR, distortion of the harmonic signal may compromise the accuracy of bipolar code sequence, leading to axial artifacts in tissue harmonic imaging after decoding. In this study, phase-encoded tissue harmonic imaging with multiplane wave (MW) transmission is compared among coding matrices (i.e., Hadamard, S-sequence and orthogonal Golay) as well as different design of bit waveform. Both simulations and experiments are conducted to validate our analysis on the coding schemes and bit waveforms. Results demonstrate that Hadamard and Golay are affected by phase distortion of harmonic waveform due to their bipolar nature. However, Hadamard can avoid these axial artifacts by sacrificing the first plane wave (PW) angle in the angular compounding. In contrast, the unipolar S-sequence is not affected by phase distortion but suffers from the reduced SNR gain compared to Hadamard. Regarding the bit waveform, the rectangular waveform provides the higher SNR but induces severe spectral distortion of the transmit phase due to its discontinuities in the envelope. This distortion becomes prominent when combined with Golay, leading to severe axial artifacts and a noticeable reduction in image contrast. It is concluded that the Hadamard with rectangular waveform and selective compounding is the optimal configuration for phase-encoded MW tissue harmonic imaging due to its higher SNR than the S-sequence and higher image quality than the orthogonal Golay.
Shen et al. (Mon,) studied this question.