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January 20, 2026Open Access

Real-Time Sub-Molecular Visualization of DNA Folding Using a Hybrid High-Speed AFM and Optical Tweezers System

Kenichi Umeda Shin’nosuke Yamanaka Motonori Imamura Fritz Nagae Shingo Fukuda Hiroki Watanabe Takayuki Uchihashi Shōji TAKADA Toshio Ando

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Key Points

The research aims to achieve real-time visualization of DNA folding at a sub-molecular level using a hybrid imaging system.
Utilized high-speed atomic force microscopy (AFM) combined with optical tweezers.
Focused on capturing the dynamic processes of DNA folding.
Employed state-of-the-art imaging techniques to enhance resolution and speed.
Demonstrated successful real-time observation of DNA folding events.
Revealed detailed insights into the mechanisms of DNA structure formation.
Showed improved visualization fidelity compared to traditional methods.

Implication

This manuscript shows advanced imaging of DNA folding dynamics in real-time, highlighting new insights into molecular behavior.

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Cite This Study

Umeda et al. (2026) studied this question.

synapsesocial.com/papers/69cd7a915652765b073a7e2e https://doi.org/10.24517/0002003988

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