Compares chromosome exchanges induced by mitomycin C in normal versus pericentric inv(9) cells, highlighting significant differences.
Several reports are available for the finding that mitomycin C (MMC) induces non-random chromosome exchanges in human cells (Nowell 1964 ; Cohen and Shaw 1964 ; Br¢ggerand Johansen 1972). It has been shown that the majority of exchanges occurs preferentially between the constitutive heterochromatin of homologous chromosomes, especially in the secondary constriction regions of chromosomes 1, 9 and 16. This may be a result of the association of these chromosome regions during interphase, either through regular somatic pairing (Rao and Nataraj an 1967) or through a particular gathering effect of MMC (Kobayashi 1960). There is little information on the mitotic feature of the somatic pairing in chromosomes with rearrangements, particulary with pericentric inversions of mammalian cells. The present study was attempted to test the effect of MMC on cells with pericentric inv (9), one of the polymorphic variations in man (Hansmann 1976; Shiraishi and Makino 1977), and to compare the frequency of MMC-induced exchanges between normal and pericentric inv (9) cells.
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Shiraishi et al. (1977) studied this question.
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