Sulfonamide derivatives as tubulin polymerization inhibitors: advances in structural mechanisms, structure–activity relationships, and therapeutic potential in cancer treatment

Key Points

• The research aims to explore the structural mechanisms and therapeutic potential of sulfonamide derivatives as inhibitors of tubulin polymerization.
• Identified sulfonamide derivatives as tubulin binding agents
• Analyzed binding interactions with the colchicine site on microtubules
• Investigated effects on tubulin polymerization and cancer cell death
• Sulfonamide derivatives effectively disrupt tubulin polymerization
• Induction of cancer cell death was observed upon treatment with these compounds
• Binding to the colchicine site was confirmed, supporting therapeutic applications