Application of a Physician–Nurse Collaborative Whole-Course Management Model in Patients With Endometrial Cancer and Atypical Endometrial Hyperplasia Undergoing Fertility-Preserving Treatment

Background: The incidence of endometrial cancer (EC) has been rising annually, and many young patients wish to preserve their reproductive potential. This study aims to evaluate the impact of a whole-course management model on treatment adherence and efficacy among patients with early-stage EC and atypical endometrial hyperplasia (AEH) seeking fertility preservation. Methods: This retrospective cohort study involved 162 patients diagnosed with EC or AEH who underwent fertility-preserving treatment at Peking University People’s Hospital between July 2010 and December 2023. Patients were divided into two groups: the control group (n = 80; diagnosed from July 2010 to June 2019) received conventional disease management, while the experimental group (n = 82; diagnosed from November 2022 to December 2023) received a physician–nurse collaborative whole-course management model. In the experimental group, each patient was assigned a dedicated nurse responsible for monitoring treatment, ensuring protocol adherence, and promptly reporting any abnormalities or disease progression to physicians. Data from both groups were collected over a one-year follow-up period. Results: No statistically significant differences in baseline characteristics, including residence, income, occupation, education, and treatment regimens, were observed between the two groups (p > 0.05). The experimental group exhibited significantly higher follow-up rates at 3 months (91.5% vs. 93.8%, p = 0.578), 6 months (64.6% vs. 46.3%, p = 0.019), and 1 year (64.6% vs. 30.0%, p < 0.001), as well as greater patient satisfaction (68.3% “very satisfied” vs. 17.5% “very satisfied”, p < 0.001). The median time to complete remission was shorter in the experimental group (6.2 months vs. 10.4 months, p = 0.007), and no disease progression was observed. Conclusions: The physician–nurse collaborative whole-course management model is effective for patients with EC and AEH undergoing fertility preservation. It significantly enhances treatment adherence, patient satisfaction, and clinical outcomes.