Demonstrates splicing inhibition regulates ribosomal protein genes in yeast, suggesting a novel mechanism of gene expression control.
Yeast ribosomal protein genes RPL18B, RPL28 and RPS22B are autoregulated by inhibition of splicing. This is demonstrated by inserting their introns into a chromosomal copy of GFP and observing repression upon induction of the cognate protein. In RPL18B and RPS22B, a predicted conserved secondary structure within the intron is required for regulation, while in RPL28 it is not.
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Granas et al. (2026) studied this question.
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