Combination of Octreotide and Oral Glucose Maintains the Blood Glucose Level and Improves Survival Rate in Rats after Monochloroacetic Acid Exposure

We report the combined therapeutic effect of subcutaneous injection of octreotide and oral glucose administration to monochloroacetic acid exposed rats. The control rats group was subcutaneously injected with 80 mg/kg sodium monochloroacetate and infused with 2 mL/hour 10% glucose solution for 10 hours 60 minutes after exposure. Group A was given 2 g/kg oral glucose after exposure, and then infused with glucose as control. Group B was given 2 g/kg oral glucose and a subcutaneous injection of 30 µg/kg octreotide after exposure, and then infused with glucose as control. The 14-day survival rate was 0.35 (control), 0.50 (group A) and 0.90 (group B). The blood glucose of group B increased to 188 mg/dl at the beginning of the glucose infusion, significantly higher than group A. Although there were significant differences in the lactate levels between the 3 groups, the levels were not abnormally high. In conclusion, our study suggests that it is important to elevate the blood glucose levels within 60 minutes after monochloroacetic acid exposure. In addition, a combination of subcutaneous octreotide and oral glucose is advantageous to maintain high blood glucose level at early stages after exposure and may be an effective therapy for monochloroacetic acid intoxication.