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April 1, 2026Open Access

Decreasing trend in prostate cancer with high serum prostate-specific antigen levels detected at first prostate-specific antigen-based population screening in Japan

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Authors

育北育秀 北川浩泉浩二 泉悟上悟 上野

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Overview

Analysis shows decreasing prostate cancer cases with high PSA levels in men aged 54-69, indicating effective screening.

Key Points

  • The study aims to analyze trends in serum PSA levels among men undergoing screening in Japan.
  • Analyzed PSA distribution data from 19,620 men aged 54-69 from 2000 to 2011.
  • Estimated baseline serum PSA values during the first screening of participants.
  • Categorized PSA distributions by age group and excluded prostate cancer patients for baseline comparisons.
  • Overall mean baseline serum PSA levels decreased from 2.64 ng/ml in 2000 to 1.30 ng/ml in 2006.
  • Participants excluding prostate cancer showed a stable PSA level of 1.46 ng/ml during the same period.
  • The 95th percentiles for age groups were identified: 2.90, 3.60, and 4.50 ng/ml for ages 54-59, 60-64, and 65-69, respectively.

Cite This Study

北川 et al. (2014) studied this question.

synapsesocial.com/papers/69cd7b275652765b073a8f3dhttps://doi.org/10.24517/00053641
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prostate cancer detection in routine clinical practice: a large cohort study in Japan2026
  2. 2PSA testing and receipt of curative treatment in elderly Japanese men with prostate cancer: a population-based study2026
  3. 3Initial outcomes of a municipality-led prostate cancer screening program: Analysis of the osaka city system in a community clinic setting2026
  4. 4Patterns of prostate-specific antigen levels for early detection of prostate cancer in sub-Saharan Africa.2026
  5. 5Early indicators of prostate cancer risk in a community-based screening program in Lagos, Nigeria.2026