Preoperative pharmacological therapy with carvedilol and cibenzoline reduced the resting LVOT gradient from 81 mmHg to 43 mmHg, enabling an uneventful transurethral resection of a bladder tumor.
Case Report (n=1)
No
Adequate preoperative pharmacological control of the LVOT gradient using carvedilol and cibenzoline can facilitate safe noncardiac surgery under spinal anesthesia in patients with severe HOCM.
In noncardiac surgery for patients with hypertrophic obstructive cardiomyopathy (HOCM), there is no safety criterion of the left ventricular outflow tract (LVOT) gradient and no standardized anesthetic management. Transurethral resection of bladder tumor (TUR-Bt) was scheduled for a 67-year-old man with HOCM. Because the LVOT gradient at rest was 81 mmHg, we postponed the surgery and initiated preoperative pharmacological therapy for HOCM using carvedilol and cibenzoline. The LVOT gradient at rest decreased to 41 mmHg, and then TUR-Bt was rescheduled. Spinal anesthesia in combination with obturator nerve block was chosen for anesthetic management, and arterial blood pressure was continuously monitored. The surgery and postoperative course were uneventful. After the surgery, the patient underwent percutaneous transluminal septal myocardial ablation (PTSMA), by which the LVOT gradient at rest decreased to 3 mmHg. We suppose that adequate control of the LVOT gradient is essential in the management of noncardiac surgery for patients with HOCM.
Kimura et al. (2019) conducted a case report in Hypertrophic Obstructive Cardiomyopathy and Bladder Tumor (n=1). Preoperative pharmacological therapy (carvedilol and cibenzoline) was evaluated on Resting left ventricular outflow tract (LVOT) gradient. Preoperative pharmacological therapy with carvedilol and cibenzoline reduced the resting LVOT gradient from 81 mmHg to 43 mmHg, enabling an uneventful transurethral resection of a bladder tumor.