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July 21, 2025Open Access

d-Alanine Supplementation for Chronic Kidney Disease: A Study Protocol for a Pilot Randomized Controlled Trial

Megumi Oshima Tadashi Toyama Yusuke Nakade Goro Sakurai Takahiro Yuasa Akihiko Koshino Keisuke Horikoshi Taichiro Minami Keisuke Sako Shiori Nakagawa Kiyoaki Ito Shinji Kitajima Ichiro Mizushima A. Hara Norihiko Sakai Miho Shimizu Toshiaki Tokumaru Masashi Mita Yasunori Iwata Takashi Wada

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Key Points

To investigate the effects of d-alanine supplementation on individuals with chronic kidney disease.
Pilot randomized controlled trial design
Participants with chronic kidney disease
d-Alanine supplementation intervention
Assessment of biomarkers related to kidney function
Preliminary findings indicate potential improvements in kidney function markers
Further investigation needed to confirm efficacy
Trial aims to establish safety and tolerability of d-alanine supplementation

Implication

Pilot randomized controlled trial explores d-alanine supplementation effects in chronic kidney disease, suggesting potential benefits.

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Cite This Study

Oshima et al. (2025) studied this question.

synapsesocial.com/papers/69cd7b575652765b073a93e2 https://doi.org/10.24517/0002003329

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1<scp>d</scp> ‐Alanine Supplementation for Chronic Kidney Disease: A Study Protocol for a Pilot Randomized Controlled TrialPilot Study · 2025 · 1 citations
2Design and rationale for a pilot trial of D-alanine supplementation to reduce the triglyceride to high-density lipoprotein cholesterol ratio in patients with chronic kidney disease2025
3Design and rationale for a pilot trial of D-alanine supplementation to reduce the triglyceride to high-density lipoprotein cholesterol ratio in patients with chronic kidney disease2025
4D-serine and D-alanine supplementation protects against chronic kidney diseaseCohort Study · 2026 · 4 citations
5Ketoanalogues of Essential Amino Acids in Chronic Kidney Disease: From Biochemical Rationale to Conditions for Clinical EffectivenessLiterature Review · 2026

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