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April 1, 2026British Journal of Pharmacology

Cordycepin alleviates ischaemic brain injury by suppressing microglia‐induced neuroinflammation via regulating the Notch1 signalling pathway

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Authors

XLXiaodong LiGZGao‐Feng ZhanXZXue Zhang

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Overview

Experimental study demonstrates cordycepin's protective effect on neuroinflammation in ischaemic stroke, suggesting new treatment avenues.

Key Points

  • This research aims to explore how cordycepin protects against ischaemic stroke through its effects on microglial activation and neuroinflammation.
  • Induced ischaemic stroke in male mice using middle cerebral artery occlusion (MCAO).
  • Assessed sensorimotor and cognitive functions, neuroinflammation, and microglial activation in vivo.
  • Established an in vitro model of ischaemic brain injury via oxygen-glucose deprivation in primary cultured microglia.
  • Investigated the effects of cordycepin intervention on these models.
  • Cordycepin treatment in MCAO mice resulted in reduced brain oedema and improved brain morphology.
  • Improved neurological deficit scores and enhanced sensorimotor and cognitive functions were observed with cordycepin.
  • Cordycepin suppressed microglial hyperactivation and proinflammatory factor expression.
  • It accelerated lysosomal degradation of the Notch1 intracellular domain, inhibiting Notch1 signalling pathway activation.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69cd7b695652765b073a9635https://doi.org/10.1111/bph.70426
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