Changes in the biological antioxidant potential and the level of oxidative stress in the blood of mice administered MPTP/p : The effects of Ferulic acid

A mouse model of Parkinsonism was created via subcutaneous administration of methyl-4-phenyl-1,2,3,6-tetrahydropyridine and probenecid (MPTP/p). Afterwards, ferulic acid (Fer) was administered orally, and changes in the biological antioxidant potential (BAP) and the level of oxidative stress (d-ROMs) in the blood were examined. BAP (μM) was 2,416±147 (mean±S.E.M, n＝6) in the control group (the disease-free model) versus 2,238±102 (a 7.4% decrease) in a group of mice with Parkinsonism induced via subcutaneous administration of MTPT/p that were orally administered a solvent alone and 2,565±91.8 (a 14.6% increase) in a group of mice with Parkinsonism induced via subcutaneous administration of MTPT/p that were orally administered Fer. In addition, d-ROMs (U.CARR) was 182±12.6 in the control group (the disease-free model) versus 232±17.0 (a 27.2% increase) in the group of mice with Parkinsonism induced with MTPT/p that were orally administered a solvent alone and 213±13.0 (an 8.0% decrease) in the group of mice with Parkinsonism induced with MTPT/p that were orally administered Fer. Administration of Fer to mice with Parkinson’s disease induced using MPTP/p presumably increased the BAP and decreased the level of oxidative stress in the blood of mice as a result of the scavenging of reactive oxygen species involved in biological regulation.