What question did this study set out to answer?

To assess the acute therapeutic effects of intravenous propranolol in patients presenting with transient left ventricular apical ballooning without coronary artery stenosis.

January 1, 2002Circulation JournalOpen Access

Effect of Intravenous Propranolol on Left Ventricular Apical Ballooning Without Coronary Artery Stenosis (Ampulla Cardiomyopathy). Three Cases.

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Why the study?

Does intravenous propranolol improve electrocardiographic and left ventricular wall motion abnormalities in female patients with takotsubo cardiomyopathy?

Population

Female patients with transient left ventricular apical ballooning without coronary artery stenosis

Design

Case_series

Authors

MKMichifumi KyumaSapporo Medical University KTKazufumi TsuchihashiSapporo Medical University YSYasuyuki ShinshiObihiro Kosei General Hospital

Discussion

Member takes

Implication

Hypothesis-generating for propranolol in takotsubo with obstruction; prospective trials needed before adoption.

Key Points

To assess the acute therapeutic effects of intravenous propranolol in patients presenting with transient left ventricular apical ballooning without coronary artery stenosis.
Administered intravenous propranolol at doses of 2 to 4 mg to evaluate acute hemodynamic and wall motion changes.
Evaluated 3 female patients (aged 61–76 years) diagnosed with ampulla (takotsubo) cardiomyopathy.
Two patients presenting with significant intraventricular pressure gradients exhibited marked improvement in electrocardiographic abnormalities and left ventricular wall motion after propranolol administration.
One patient without an intraventricular pressure gradient showed no improvement in wall motion or electrocardiographic abnormalities.

Structured PICO

Does intravenous propranolol improve electrocardiographic and left ventricular wall motion abnormalities in female patients with takotsubo cardiomyopathy?

Population

Female patients with transient left ventricular apical ballooning without coronary artery stenosis (takotsubo cardiomyopathy)

Intervention

Intravenous propranolol (2-4 mg)

Outcome

Improvement in electrocardiographic and left ventricular wall motion abnormalitiessurrogate

Intravenous propranolol may acutely improve wall motion and ECG abnormalities in takotsubo cardiomyopathy patients who have dynamic intraventricular obstruction.

Cite This Study

Kyuma et al. (2002) studied this question.

synapsesocial.com/papers/69cdc0b84161e6a33dea480c https://doi.org/10.1253/circj.66.1181

Topics

Echocardiography

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Effect of Intravenous Propranolol on Left Ventricular Apical Ballooning Without Coronary Artery Stenosis (Ampulla Cardiomyopathy). Three Cases.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Effect of Intravenous Propranolol on Left Ventricular Apical Ballooning Without Coronary Artery Stenosis (Ampulla Cardiomyopathy). Three Cases.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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