August 29, 2021New England Journal of Medicine744 citationsOpen Access
Effect of Salt Substitution on Cardiovascular Events and Death
Structured PICO
Does salt substitute reduce stroke, major cardiovascular events, and death from any cause in persons with a history of stroke or who are 60 years of age or older with high blood pressure?
P
Population
Persons who had a history of stroke or were 60 years of age or older and had high blood pressure
I
Intervention
Salt substitute
C
Comparator
Regular salt
O
Outcome
Stroke, major cardiovascular events, and death from any causehard clinical
Salt substitution effectively lowers the rates of stroke, major cardiovascular events, and all-cause mortality compared to regular salt in high-risk patients.
Abstract
Among persons who had a history of stroke or were 60 years of age or older and had high blood pressure, the rates of stroke, major cardiovascular events, and death from any cause were lower with the salt substitute than with regular salt. (Funded by the National Health and Medical Research Council of Australia; SSaSS ClinicalTrials.gov number, NCT02092090.).
Cite This Study
Neal et al. (2021) studied this question.