Why the study?
Does a single dose of methadone administered at anesthesia induction reduce postoperative morphine consumption in patients undergoing moderate-to-severely painful surgery?
Does a single dose of methadone administered at anesthesia induction reduce postoperative morphine consumption in patients undergoing moderate-to-severely painful surgery?
A single preoperative dose of methadone may be an effective strategy to reduce postoperative morphine consumption in moderate-to-severely painful surgeries.
May warrant single-dose methadone at induction for opioid sparing after painful surgery; extends limited RCT evidence.
A single dose of methadone administered at anesthesia induction prior to moderate-to-severely painful surgery is a possible strategy to reduce postoperative morphine consumption.
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Bastian et al. (2019) studied this question.
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