PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
April 3, 2026Microbiome3 citationsOpen Access

Tryptophan metabolism mediated by the gut microbiota inhibits pyroptosis via the AhR signaling pathway to maintain intestinal epithelial homeostasis

MLMengqi LiuSLShouren LiYCYalei Cui

Key Points

  • Investigate how tryptophan metabolism and gut microbiota affect pyroptosis and intestinal health.
  • Targeted regulation of Lactobacillus reuteri
  • Assessment of tryptophan metabolism
  • Evaluation of pyroptosis markers
  • Analysis of intestinal epithelial homeostasis
  • Inhibition of pyroptosis was observed
  • Improvement in intestinal epithelial homeostasis was noted
  • Indicated a potential therapeutic approach using Lactobacillus reuteri

Abstract

Our results provide the first evidence that targeting the regulation of Lactobacillus reuteri and tryptophan metabolism is a promising strategy for inhibiting pyroptosis and improving intestinal epithelial homeostasis.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69cf58fd5a333a8214609bbdhttps://doi.org/10.1186/s40168-026-02408-7
Ask AI
Helpful
Bookmark
Share
View Full Paper