Development of a surface enhanced Raman scattering lateral flow immunoassay with prolonged reproducibility and stability over time

Sian Sloan-Dennison; Ben Clark; Kathleen  M Scullion; Fiona Smillie; Stacey Laing; Paul Fineran; Joanne Mair; Cicely Rathmell; Dieter Bingemann; Jonathan Faircloth; D. J. Creasey; Neil C. Shand; Christopher J. Weir; James W. Dear; Duncan Graham; Karen Faulds

doi:10.1039/d6an00053c

January 1, 2026The AnalystOpen Access

Development of a surface enhanced Raman scattering lateral flow immunoassay with prolonged reproducibility and stability over time

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Key Points

This research aims to enhance the stability and reproducibility of lateral flow immunoassays using surface enhanced Raman scattering technology.
Developed a novel lateral flow immunoassay that integrates surface enhanced Raman scattering measurements.
Tested the performance over time to assess stability and reproducibility in outputs.
Conducted quantitative analyses to evaluate sensitivity and effectiveness in detecting targets.
Demonstrated prolonged reproducibility of the immunoassay results over extended periods.
Achieved excellent sensitivity comparable to traditional methods, making it suitable for point-of-care applications.
Indicated that the integration of SERS improves the overall performance of LFIAs.

Implication

Development of a novel lateral flow immunoassay shows improved reproducibility and stability over time, indicating potential for point-of-care applications.

Abstract

Lateral flow immunoassays (LFIAs) coupled to surface enhanced Raman scattering (SERS) measurements can produce quantitative outputs with excellent sensitivity. Despite this, they have not been adopted into point-of-care (POC) scenarios,...

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Cite This Study

Sloan-Dennison et al. (2026) studied this question.

synapsesocial.com/papers/69cf5cb15a333a821460a483 https://doi.org/10.1039/d6an00053c

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Development of a surface enhanced Raman scattering lateral flow immunoassay with prolonged reproducibility and stability over time

Key Points

Implication

Abstract

Discussion

Cite This Study

Development of a surface enhanced Raman scattering lateral flow immunoassay with prolonged reproducibility and stability over time

Key Points

Implication

Abstract

Discussion

Cite This Study

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