April 3, 2026International Forum of Allergy & Rhinology2 citationsOpen Access
Biofilm Exoproteins From Staphylococcus Species Impede Re‐Epithelialization of Nasal Epithelial Cells During Wound Healing and Cease Ciliary Beat Frequency
The aim is to investigate how Staphylococcal biofilm exoproteins affect nasal epithelial cell healing.
Assessment of mucociliary function in the presence of biofilm exoproteins
Evaluation of nasal epithelial cell re-epithelialization
Measurement of cytotoxicity and inflammation levels
Analysis of reactive oxygen species (ROS) release
Biofilm exoproteins significantly hindered re-epithelialization of nasal epithelial cells
Mucociliary function was reduced due to exoprotein activity
Inflammatory responses were elicited alongside cytotoxic effects
Reactive oxygen species (ROS) release was concurrently diminished
Abstract
Staphylococcal biofilm exoproteins hindered mucociliary function and re-epithelialization of the nasal epithelium, caused cytotoxicity, elicited inflammation, and concurrently reduced ROS release.