Molecular Methods to Detect and Quantify Fungal Communities in Cystic Fibrosis Airway Specimens

Matthew K. Fought; Gina Hong; Alex Quinn; Brandie D. Wagner; Charles E. Robertson; J. Kirk Harris; Theresa A. Laguna

doi:10.1002/ppul.71598

March 31, 2026Pediatric Pulmonology

Molecular Methods to Detect and Quantify Fungal Communities in Cystic Fibrosis Airway Specimens

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Key Points

The aim is to explore molecular techniques for identifying and quantifying fungi in cystic fibrosis airways.
Used next-generation sequencing (NGS) to analyze airway specimens
Compared findings with traditional methods for detecting fungi
Evaluated potential for OP swabs in clinical diagnosis
NGS identified a higher diversity of fungi in the airways of individuals with cystic fibrosis
OP swabs show promise for reliable fungal detection
Potential to reduce reliance on more invasive procedures

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Implication

Analysis identifies fungal presence in airway specimens of cystic fibrosis, suggesting new diagnostic approaches.

Abstract

NGS identified more distinct fungi in the airways of pwCF and OP swabs show potential for reliably detecting fungi in the airway, mitigating the need for ES. Future work will assess fungal-bacterial interactions and associations with clinical outcomes.

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Fought et al. (2026) studied this question.

synapsesocial.com/papers/69cf5d1f5a333a821460ac9f https://doi.org/10.1002/ppul.71598

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Molecular Methods to Detect and Quantify Fungal Communities in Cystic Fibrosis Airway Specimens

Key Points

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Implication

Abstract

Discussion

Cite This Study

Molecular Methods to Detect and Quantify Fungal Communities in Cystic Fibrosis Airway Specimens

Key Points

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Implication

Abstract

Discussion

Cite This Study

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