Research shows no link between placental corticotropin releasing hormone and children's psychiatric outcomes, suggesting alternative approaches are needed.
Contrasting theory and findings in smaller samples at younger ages, evidence from this study did not support pCRH as a plausible maternal neuroendocrine mediator for the intergenerational transmission of stress effects on offspring internalizing psychopathology during middle childhood. Future research exploring potential for waning associations across early childhood or other potential mechanisms is warranted.
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Sullivan et al. (2026) studied this question.
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