A meso -acyl-BODIPY-based fluorogenic probe for the selective monitoring of aldo-keto reductase 1C1 in living cells

Yeri Kim; Le Bich Hang Pham; Jae Hee Lee; Jungmin Lee; Youngmi Kim

doi:10.1039/d6cc00473c

January 1, 2026Chemical CommunicationsOpen Access

A meso -acyl-BODIPY-based fluorogenic probe for the selective monitoring of aldo-keto reductase 1C1 in living cells

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Key Points

The research aims to develop a specific probe for monitoring the activity of aldo-keto reductase 1C1 in living cells.
Synthesis of meso-acyl-BODIPY-based fluorogenic probe
Testing the probe's selectivity against AKR1C1 isoforms
Application of the probe in living cell imaging
The developed probe selectively monitored AKR1C1 activity.
Successful imaging in living cells demonstrated the probe's efficacy.
The probe allowed differentiation between AKR1C1 and its isoforms.

Implication

Fluorogenic probe enables selective imaging of AKR1C1 in living cells, suggesting potential for steroid metabolism studies.

Abstract

Aldo-keto reductase 1C1 (AKR1C1) plays critical roles in steroid metabolism, but the selective imaging of AKR1C1 activity over that of its isoforms is highly challenging. The BODIPY-based fluorogenic probe 1-CO ...

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Cite This Study

Kim et al. (2026) studied this question.

synapsesocial.com/papers/69cf5d775a333a821460b305 https://doi.org/10.1039/d6cc00473c

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A meso -acyl-BODIPY-based fluorogenic probe for the selective monitoring of aldo-keto reductase 1C1 in living cells

Key Points

Implication

Abstract

Discussion

Cite This Study

A meso -acyl-BODIPY-based fluorogenic probe for the selective monitoring of aldo-keto reductase 1C1 in living cells

Key Points

Implication

Abstract

Discussion

Cite This Study

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