Interventions with Yanhusuo reveal protective effects against brain injury in nerve structure, suggesting potential therapeutic pathways.
YHTA protects against nerve damage caused by CCH in the hippocampus. The mechanism may involve activation of the HIF-1α/VEGF/VEGFR-2 pathway, modulating the expression of apoptosis-related proteins Bcl-2 and Bax, and inhibiting nerve cell apoptosis, thereby promoting the generation of microvessels in brain tissue, improving blood flow supply, accelerating the repair of neurons, and playing a role in neuroprotection.
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Tian et al. (2026) studied this question.
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