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Findings reveal that redox-driven processes affect the behavior of astatine-211, suggesting implications for radiopharmaceuticals.
These results identify redox-driven speciation and subsequent hydrolysis/aggregation as key chemical processes contributing to the in vivo behavior of free ²¹¹At. Understanding and controlling astatine redox chemistry is therefore critical for improving the stability, safety, and translational development of ²¹¹At-based radiopharmaceuticals.
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Dong et al. (2026) studied this question.
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